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Nutrigenomics

Nutrigenomics (n):

is the study of the effects of food and food/plant components on gene expression. 


Scientists and the medical community used to think that our genes were "set". And as a result, we were destined to have the same medical problems that plagued our parents, grandparents or other family members. Because those "problems" were set in our genes.


But, today, we now know that we can alter the expression of 96% of our genome through providing the proper information to our bodies. This information in the form of food and food/plant components tells our bodies at the cellular level what to do and how to function.

Biohacking

“crack the code” on your DNA 

enables the body to get back into balance and perform at optimal levels

improve health and lifespan

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The Brain

Biohacking Your Brain Health

Dr. David Perlmutter, MD is a well-known educator in the area of brain health. He has been called the leading integrative medicine neurologist in North America today. He has written books such as "Grain Brain", "Brain Maker", and "Grain Brain - The Whole Life Plan". 

He talks about the decline of brain health stemming from:
1. inflammation -> 2. free radicals -> 3. brain cell death. 

He states, based on research that was published in Therapeutic Advances in Chronic Disease, that the level of inflammation in the body is correlated to both the rate of degeneration of the brain, as well as the degree of cognitive impairment during aging. 

There are many reasons to decrease inflammation in the body, and brain health is just one of them.

One important way to control inflammation in the body is to reduce sugar intake. High blood sugar is a common contributor in our modern day diets to inflammation. It’s not the only cause of inflammation, but it is a MAJOR one that is under our control. 

Secondly, another potent and easy way to decrease inflammation is NRF2 activation. NRF2 increases the expression of anti-inflammatory genes and decreases expression of pro-inflammatory genes. 

Overall result -> decreased inflammation. 

Not only does NRF2 activation directly address inflammation, but it powerfully activates the production of anti-oxidants, (including the master anti-oxidant, glutathione), which can get to work on quenching an over-abundance of free radicals. 

If Dr. Perlmutter is right that:

Inflammation -> Free Radicals -> Brain Cell Death

And NRF2 activation decreases BOTH Inflammation AND free radicals…

I can tell you how grateful I am to have NRF2 activation in my toolkit for my own health, as well as that of my friends and family.

Nrf2

The Nrf2 protein was first discovered in 1992. The research on this vitally important protein has grown exponentially over the past decade. In 2015 Washington State University published a literature review of the Nrf2 research and they concluded that;

-"we may be on the verge of a new literature on the health effects of Nrf2 which may well become the most extraordinary therapeutic and most extraordinary preventative breakthrough in the history of medicine."

Acta Physiologica Sinica, February 25, 2015, 67(1): 1–18 DOI: 10.13294/j.aps.2015.0001 http://www.actaps.com.cn

Review 1

Nrf2, a master regulator of detoxification and also antioxidant, anti-inflammatory and other cytoprotective mechanisms, is raised by health promoting factors

Martin L Pall1,*, Stephen Levine2
1Washington State University, Portland, Oregon 97232-3312, USA; 2Allergy Research Group, Alameda, California 94502, USA

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Mitochondria

Energy

Mitochondria are described as the "power house" of the cell and produce 90-95% of your bodies cellular energy. Literature states that mitochondria reside in every cell of our bodies, and that each cell has thousands and in some cases possibly even tens of thousands of mitochondria. some of the highest concentrations of cellular mitochondria exist in our livers, brain, hearts, eyes and muscles. 

Dr. Pearlmutter suggests that if you could extract all of your mitochondria and place it on a scale...it would make up 10% of your body weight.

Mitochondria are unfortunately fairly fragile and prone to dysfunction and disease. Approximately 1 in 2,500 adults, teens and children are affected, making mitochondrial disease more common than childhood cancers. Mitochondrial dysfunction is proven to be at the root of many common diseases and conditions that affect young and old, from Autism, Parkinson's, Alzheimer's,  ALS, Huntington's Disease, Muscular Dystrophy, epilepsy, chronic fatigue, diabetes, fibromyalgia and even some cancers.

So now that we have a little understanding of the severity and multitude of problems associated with mitochondrial dysfunction, it becomes obvious that we must maintain good mitochondrial health. 

So how do we keep our mitochondria healthy? There's good news!!! Our bodies were designed with the necessary tools! The NRF1 protein helps our bodies restore dysfunctional mitochondria and also build bigger and stronger mitochondria. And through Nutrigenomics it is possible to activate this protein at a much higher level than ever thought possible.

NRF1

Then NRF1 Protein is present in all of our bodies. But as we age or with certain mitochondrial diseases and dysfunctions, this protein is not working optimally. We can biohacking our bodies and put this protein back to work!

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Probiotics

Additional Information

The powerful health benefits of probiotics include improving gut health, increasing nutrient intake, boosting the immune system, weight loss, improving mood, treating diarrhea, and preventing serious illnesses like cancer and Crohn’s disease. They help to maintain the vital balance of good and bad bacteria in our digestive tract while alleviating muscle pain and fatigue.

What are Probiotics?

Probiotics are live bacteria that, when consumed through foods or supplements, are beneficial to our digestive system. They are also called good, healthy or friendly bacteria. Our digestive or gastrointestinal tract usually has trillions of gut bacteria and yeast, collectively known as ‘gut flora’. For the gastrointestinal system to function properly, the gut flora must be in balance. This helps counteract the negative effects of certain dietary choices, illnesses or medications.


When a person contracts a bacterial infection, antibiotics are often turned to as the immediate solution, but antibiotics kill bacteria arbitrarily, wiping out both good and bad bacteria in the intestinal tract. By eliminating the beneficial bacteria, the body is vulnerable to various digestive issues. Rapid replacement of these beneficial bacteria is very important, and introducing probiotics to a health regimen is an increasingly popular method to do just that.


Health Benefits

Gut Health

Probiotics contain important strains of bacteria like lactobacilli and bifidobacteria which maintain and strengthen the gastrointestinal tract and helps overall health.


Irritable Bowel Syndrome

Irritable bowel syndrome (IBS) is not the result of a known organic factor, and is characterized by abdominal pain, unpredictable bowel movements, and bloating. A number of different causes have been cited, including environmental, physical, and mental stress, Adding probiotics to a health regiem, or diet is shown to decrease the severity and frequency of IBS. Particularly, the strain called Bifidobacterium Infantis appears to be the most successful in trials to this point.


Antibiotic-associated Diarrhea

Diarrhea is on the other extreme of digestive issues, and studies show that probiotics can also help regulate the intestinal processes to decrease diarrhea. This uncomfortable affliction can be labeled as antibiotic-associated diarrhea (AAD), acute infectious diarrhea, or Clostridium difficile disease (CDD), a condition also related to the use of antibiotics. Antibiotics can be very damaging to your intestinal processes, frequently resulting in AAD or CDD. By replenishing the good bacteria eliminated by the antibiotics with probiotics in your diet, it is possible to decrease or eliminate chronic or individual episodes of diarrhea.


Constipation

Another common reason for the use of probiotics is as a treatment for constipation. Probiotics can balance the enzyme activity and help to speed up the process of digestion and excretion, thereby eliminating the uncomfortable condition of constipation that afflicts many people in varying levels of severity.


Gastroenteritis

Gastroenteritis is one of the main causes of acute diarrhea. It is the inflammation of the mucous membrane of the intestine. Research studies suggest that probiotics may help in decreasing gastrointestinal symptoms in children suffering from atopic dermatitis. Probiotics such as Bifidobacteria and Streptococcus thermophilus help in preventing diarrhea in infants (rotaviral diarrhea) and traveler’s diarrhea.


Heart Health

Probiotics contain bacteria that are effective in lowering total and LDL (bad) cholesterol. Probiotic bacteria absorb fiber from the intestines and as a result, they generate propionic acid. This particular acid has the ability to reduce the production of cholesterol by the liver.


Mental Health Conditions

Research shows that they play a major role in improving mood because there is a strong connection between the gut and the brain. People who were suffering from sadness were given probiotics and they showed signs of improvement and a reduction in negative thoughts. Studies are being undertaken to test if probiotics can help alleviate depression.


Immune System

By consuming probiotics and actively working to maintain the balance of good and bad bacteria within your gastrointestinal system, you can actually improve the strength and efficiency of your immune system. Probiotic bacteria can inhibit the reproduction and survival of harmful pathogens in the gut, and they can also regulate the number of antibodies present in the intestines. This, in turn, leads to a stronger immune system that is better suited and prepared to fight off disease and illness. Autoimmune disorders like rheumatoid arthritis, Crohn’s Disease, and ulcerative colitis are more common when the levels of good and bad bacteria are imbalanced, so probiotics can help regulate intestinal homeostasis, and even save your life.


Weight Loss

Studies show that probiotics may help in weight loss and tackle belly fat and that obese people have 70% or less gut flora than people who are at a healthy weight. Further research also showed that eating yogurt, which is a natural source of probiotic bacteria, prevented age-associated weight gain. Certain gut bacteria may also change insulin sensitivity in people, helping maintain stable sugar levels and burning fat which the body would have otherwise stored.


Yeast Infections

The consistent use of probiotics has also been effective in the treatment of yeast infections in women. Studies have also reflected that these types of probiotics can help to treat urinary tract infections and bacterial vaginosis, as well as the more common yeast vaginitis. Previous modes of treatment did not approach the problem with an oral or intestinal solution, but various Lactobacilli strains of probiotics can be ingested orally and the beneficial effects will treat symptoms in the reproductive system.


Skin Health

Gut health is linked to skin health. When the gut flora is in balance, the body is able to absorb nutrients and eliminate toxins. This helps prevent chronic inflammation, which causes acne and other skin problems.


Nutrient Intake

Probiotics can positively impact bio-availability, which means that the body is more capable of extracting beneficial nutrients from the food we eat so none of it goes to waste. Higher levels of these nutrients can positively affect the body in countless ways, including increased bone health and blood oxygenation, and improved memory.


Chronic Fatigue

Adding probiotics to your diet can also help reduce chronic fatigue. Recent studies have shown a link between intestinal bacteria imbalance, the immune system, and Chronic Fatigue Syndrome (CFS). Although CFS is not fully understood, the symptoms can be reduced or eliminated by the use of probiotics.


Lactose Intolerance

This inability of the body to process lactose (due to a lack of the enzyme lactase) can cause serious digestive problems, but some studies have shown probiotics to lessen the effects of lactose intolerance when lactose is ingested. This is due to a strain of probiotics called Acidophilus, as well as other similar types of bacteria, which produce similar effects as lactase and are able to break down and promote the digestion of lactose. Using probiotics does not eliminate the condition of lactose intolerance in individuals, but it can alleviate certain irritating and painful symptoms.


Fever

Bifidobacteria and Lactobacillus acidophilus may help in treating the symptoms of cold, cough, and fever.


Cancer

Probiotics may also be beneficial in preventing cancer. Research studies suggest that probiotics may help in slowing the growth of certain cancerous tumors.


Types of Probiotics

There are a number of different probiotic types or “strains” that are specifically chosen for their unique properties, depending on what gastrointestinal symptom the user would like to alleviate or eliminate. The most commonly used types are:

  • Lactobacilli 
  • Bifidobacteria
  • Bacilli 
  • Various types of yeast like Saccharomyces boulardii

Types of Probiotics

There are a number of different probiotic types or “strains” that are specifically chosen for their unique properties, depending on what gastrointestinal symptom the user would like to alleviate or eliminate. The most commonly used types are:

  • Lactobacilli 
  • Bifidobacteria
  • Bacilli 
  • Various types of yeast like Saccharomyces boulardii

Find out more